Concurrent Session 12: Inflammation and Immunity

NF-kB Mediates Inflammation-Induced Metabolic and Senescence Changes in OA

Date/Time: Sunday, May 5, 2019 - 8:45 AM to 10:15 AM
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Description:

NF-kB Mediates Inflammation-Induced Metabolic and Senescence Changes in OA
Yousef Abu-Amer, PhD - Washington University

This presentation will focus on deciphering mechanistic aspects and contribution of inflammation to OA development. Our work investigates the hypothesis that the NF-kB pathway, which is considered the primary gatekeeper of inflammatory responses, is critical for OA development. We further postulate that targeting NF-kB in a cell-specific manner may serve as a viable therapeutic target. Using genetic and pharmacologic approaches, we have established that the classic NF-kB pathway, dominated by IKK2, modulates OA by targeting chondrocytes. Specifically, we offer novel evidence that this IKK2-mediated inflammatory process involves induction of SASP factors, which appears to be mediated in part by the metabolic enzyme LDHA, inhibition of which dampens key SASPs, such as IL-6 and CCL2. Thus, IKK2 induction of LDHA in chondrocytes should be an attractive target to modulate OA.

Followed by select abstract presentations.

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