Plenary Session 3: Mechanobiology

Mechanotransduction Pathways and Relevance to Human OA

Date/Time: Friday, May 3, 2019 - 10:45 AM to 12:15 PM
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Description:

Mechanotransduction Pathways and Relevance to Human OA
Kate Poole, PhD - University of New South Wales - Sydney

The ion channel TRPV4 can be activated by mechanical stimuli applied directly at the interface between cells and their substrate. We are investigating how both cell endogenous and cell exogenous factors regulate mechanical signalling via TRPV4. We aim to characterise how modulation of this signal transduction pathway impacts the balance between physiology and pathophysiology within articular cartilage.

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