Plenary Session: Keynote Lecture

Pathogenic Mechanisms of Obesity-Induced Osteoarthritis: New Clues from Old Joints

Date/Time: Thursday, May 2, 2019 - 6:35 PM to 7:15 PM
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Description:

Pathogenic Mechanisms of Obesity-Induced Osteoarthritis: New Clues from Old Joints
Clifford Rosen, MD - Maine Medical Center Research Institute

Obesity is one of the most common phenotypes associated with osteoarthritis. The unifying mechanism thought to be operative is excessive loading on the joints. However, centripetal obesity is also associated with the release of systemic adipokines and cytokines that could impact inflammatory pathways in the joint. In addition, there are local fat depots adjacent to the knee and other joints which could have paracrine actions.  Obesity is also associated with greater bone marrow adipose tissue, and bone marrow adipocytes can have both paracrine and endocrine activity which may contribute to local joint disease.  Whether bone marrow lesions seen on MRI contribute to the pathophysiology of OA in the context of obesity remains to be determined.  In sum, obesity affects the pathophysiology and progression  of OA through multiple mechanisms. Studies on the adipocyte progenitor and its role in this disease will be discussed.

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